The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation
represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex …

DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

DNA-methylation patterns are important for regulating genome functions, and are
determined by the enzymatic processes of methylation and demethylation. The …

DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …

The pattern of DNA methylation plays an important role in regulating different genome
functions. To test the hypothesis that DNA methylation is a reversible biochemical process …

Mutation of FMR1 results in fragile X mental retardation 1. The most common FMR1 mutation
is expansion of a CGG repeat tract at the 5 end of FMR1 (refs 2, 3, 4), which leads to …

Aging is the most important risk factor for the development of most adult malignancies. The
molecular events responsible for this striking association remain under investigation, but …

De novo methylation of CpG islands within the promoters of eukaryotic genes is often
associated with their transcriptional repression, yet the methylation of CpG islands located …