The Sp-family of transcription factors

G Suske - Gene, 1999 - Elsevier
GC-boxes and related motifs are frequently occurring DNA-elements present in many
promoters and enhancers. In contrast to other elements it was generally thought that the …

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

S Philipsen, G Suske - Nucleic acids research, 1999 - academic.oup.com
One of the most common regulatory elements is the GC box and the related GT/CACC box,
which are widely distributed in promoters, enhancers and locus control regions of …

CpG island methylator phenotype in colorectal cancer

M Toyota, N Ahuja, M Ohe-Toyota… - Proceedings of the …, 1999 - National Acad Sciences
Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

KD Robertson, E Uzvolgyi, G Liang… - Nucleic acids …, 1999 - academic.oup.com
DNA methylation in mammals is required for embryonic development, X chromosome
inactivation and imprinting. Previous studies have shown that methylation patterns become …

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression

G Deng, A Chen, J Hong, HS Chae, YS Kim - Cancer research, 1999 - AACR
Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …

Methylation profiling of CpG islands in human breast cancer cells

THM Huang, MR Perry, DE Laux - Human molecular genetics, 1999 - academic.oup.com
CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

DNA methylation represses transcription in vivo

Z Siegfried, S Eden, M Mendelsohn, X Feng… - Nature …, 1999 - nature.com
DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

A Catteau, WH Harris, CF Xu, E Solomon - Oncogene, 1999 - nature.com
Reduced expression of BRCA1 has been reported in sporadic breast cancer, although the
mechanisms underlying this phenomenon remain unclear. Abnormal methylation leading to …

Cytosine methylation and mammalian development

CP Walsh, TH Bestor - Genes & development, 1999 - genesdev.cshlp.org
Programmed methylation and demethylation of regulatory sequences has been proposed to
play a central role in vertebrate development. We report here that the methylation status of …

[HTML][HTML] The sins of the fathers and mothers: genomic imprinting in mammalian development

SM Tilghman - Cell, 1999 - cell.com
), came as quite a surprise and forced classical Mendelian genetics to undergo a number of
revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing …