GC-boxes and related motifs are frequently occurring DNA-elements present in many
promoters and enhancers. In contrast to other elements it was generally thought that the …

One of the most common regulatory elements is the GC box and the related GT/CACC box,
which are widely distributed in promoters, enhancers and locus control regions of …

Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …

DNA methylation in mammals is required for embryonic development, X chromosome
inactivation and imprinting. Previous studies have shown that methylation patterns become …

Microsatellite instability (MSI) has been described in tumors from patients with hereditary
nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

Reduced expression of BRCA1 has been reported in sporadic breast cancer, although the
mechanisms underlying this phenomenon remain unclear. Abnormal methylation leading to …

Programmed methylation and demethylation of regulatory sequences has been proposed to
play a central role in vertebrate development. We report here that the methylation status of …

), came as quite a surprise and forced classical Mendelian genetics to undergo a number of
revisions. The discovery of imprinting also presents us with a genetic paradox: by silencing …