Cell therapy: achievements and perspectives

C Bordignon, C Carlo-Stella, MP Colombo… - …, 1999 - haematologica.org
BACKGROUND AND OBJECTIVE: Cell therapy can be considered as a strategy aimed at
replacing, repairing, or enhancing the biological function of a damaged tissue or system by …

Dendritic cells: development, function and potential use for cancer immunotherapy

D Avigan - Blood reviews, 1999 - Elsevier
Dendritic cells (DC) are potent antigen presenting cells that are essential for the initiation of
primary immune responses. They richly express MHC, costimulatory and adhesion …

Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in …

Y Osman, M Takahashi, Z Zheng, T Koike, K Toba… - Leukemia, 1999 - nature.com
Dendritic cells (DC), the most potent'professional'antigen-presenting cells, hold promise for
improving the immunotherapy of cancer. In this study, we investigated the ability of normal …

[HTML][HTML] Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α

C Wang, HM Al-Omar, L Radvanyi, A Banerjee… - Experimental …, 1999 - Elsevier
Adoptive immunotherapy in form of donor leukocyte infusions is effective in a significant
number of patients with chronic myeloid leukemia (CML) that have relapsed after allogeneic …

A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells …

GJA ten Bosch, JH Kessler, AM Joosten… - Blood, The Journal …, 1999 - ashpublications.org
Peptides corresponding to the fusion site in 210 kD BCR-ABL protein b3a2 (p210b3a2)
were previously shown to bind to several HLA class I and II alleles. We have found that b3a2 …

Dendritic cell immunotherapy for cancer: Application to low‐grade lymphoma and multiple myeloma

DNJ Hart, GR Hill - Immunology and cell biology, 1999 - Wiley Online Library
The confirmation that most cancers express one or more molecular changes, which may act
as tumour‐associated antigens (TAA), combined with the knowledge that T lymphocytes …

Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors

M Brown, DH Davies, MA Skinner, G Bowen… - Cancer Gene …, 1999 - nature.com
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-
presenting cell type of the immune system combined with the recent development of …

Calcium signaling induces acquisition of dendritic cell characteristics in chronic myelogenous leukemia myeloid progenitor cells

FHC Engels, GK Koski, I Bedrosian… - Proceedings of the …, 1999 - National Acad Sciences
Effective host T lymphocyte sensitization to malignant cells depends on successful antigen
presentation. In this study, we examined the capacity of malignant myeloid progenitor cells …

Report from the International Union Against Cancer (UICC) Tumor Biology Committee: UICC workshop on the use of dendritic cells in cancer clinical trials

ML Salgaller, M Thurnher, G Bartsch… - … Journal of the …, 1999 - Wiley Online Library
At this workshop, clinicians active in the use of dendritic cells all expressed the need to have
an available supply of interleukin (IL)‐4. There was discussion that unless some institution …

T cell-based immunotherapy for cancer: a virtual reality?

LG Lum - CA: A Cancer Journal for Clinicians, 1999 - europepmc.org
The goal of harnessing the immune system to recognize tumor as" nonself" is not new. Now,
thanks to new knowledge and new techniques, however, modalities that seek to activate the …