The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Using a compound microscope and the blood of several animals (including the elephant!),
the English anatomist, TW Jones, discovered, in 1846, that some white blood cells contained …

Histamine regulates neurotransmitter release in the central and peripheral nervous systems
through H3 presynaptic receptors. The existence of the histamine H3 receptor was …

It is now widely recognized that histamine acts as a neurotransmitter in the mammalian
central nervous system. Three selective histamine receptors have been described, all of …

Antihistamines are efficacious drugs to be used for the symptomatic relief of allergic
diseases. The safety issue of antihistamines is of central importance because of their …

Histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA,
which is essential for the incorporation of histidine into proteins. This amino acid has …

Histamine H₃ receptorâ•’mediated inhibition of noradrenaline release in the
human brain Page 1 Fundam. Clin. Pharmacol. 13 (1999) 120-122 0 Elsevier, Paris Rapid …

In unanaethetised rats with a single injection of compound 48/80, a mast cell degranulator
(0.75 mg kg− 1, ip), gastric lesions occurred with increased serum serotonin and histamine …

Background Hyperresponsiveness to histamine is a key feature of a variety of pathological
conditions, including bronchial asthma, food allergy, colitis ulcerosa, and topical allergic …

Novel branched N-alkylcarbamates and aliphatic ethers derived from 3-(1 H-imidazol-4-yl)
propanol were prepared. The compounds were investigated on two functional histamine H3 …