Heparin in inflammation: potential therapeutic applications beyond anticoagulation
DJ Tyrrell, AP Horne, KR Holme, JMH Preuss… - Advances in …, 1999 - Elsevier
Heparin has been used extensively in the clinical setting as an anticoagulant. The properties
of this polymer were first noted by McLean during his second year as a medical student at …
of this polymer were first noted by McLean during his second year as a medical student at …
Eukaryotic glycosylation: whim of nature or multipurpose tool?
G Reuter, HJ Gabius - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
Protein and lipid glycosylation is a ubiquitous phenomenon. The task of cataloguing the
great structural variety of the glycan part has demanded considerable efforts over decades …
great structural variety of the glycan part has demanded considerable efforts over decades …
Stromal cell-derived factor-1α associates with heparan sulfates through the first β-strand of the chemokine
A Amara, O Lorthioir, A Valenzuela, A Magerus… - Journal of Biological …, 1999 - ASBMB
Biological properties of chemokines are believed to be influenced by their association with
glycosaminoglycans. Surface plasmon resonance kinetic analysis shows that the CXC …
glycosaminoglycans. Surface plasmon resonance kinetic analysis shows that the CXC …
Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary …
The role of various adhesion molecules in lymphocyte homing to the brain and in
inflammatory autoimmune disease of the central nervous system (CNS) was examined in …
inflammatory autoimmune disease of the central nervous system (CNS) was examined in …
Robert Feulgen Lecture 1998: Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines
K Ebnet, D Vestweber - Histochemistry and cell biology, 1999 - Springer
Attachment of leukocytes to the blood vessel wall initiates leukocyte extravasation. This
enables leukocytes to migrate to and accumulate at sites of tissue injury or infection where …
enables leukocytes to migrate to and accumulate at sites of tissue injury or infection where …
Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer
MB Fairbanks, AM Mildner, JW Leone… - Journal of Biological …, 1999 - ASBMB
Human platelet heparanase has been purified to homogeneity and shown to consist of two,
non-covalently associated polypeptide chains of molecular masses 50 and 8 kDa. Protein …
non-covalently associated polypeptide chains of molecular masses 50 and 8 kDa. Protein …
Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae : identification of Opa adhesiotopes on the N‐domain of CD66 …
M Virji, D Evans, A Hadfield, F Grunert… - Molecular …, 1999 - Wiley Online Library
The human pathogens Neisseria meningitidis and Neisseria gonorrhoeae express a family
of variable outer membrane opacity‐associated (Opa) proteins that recognize multiple …
of variable outer membrane opacity‐associated (Opa) proteins that recognize multiple …
Ovine Osteopontin: II. Osteopontin and αvβ3 Integrin Expression in the Uterus and Conceptus During the Periimplantation Period
Osteopontin (OPN) is an acidic 70-kDa glycoprotein that is cleaved by proteases to yield 45-
kDa and 24-kDa fragments. The 70-kDa and 45-kDa proteins contain a Gly-Arg-Gly-Asp-Ser …
kDa and 24-kDa fragments. The 70-kDa and 45-kDa proteins contain a Gly-Arg-Gly-Asp-Ser …
Solution Structure and Dynamics of the CX3C Chemokine Domain of Fractalkine and Its Interaction with an N-Terminal Fragment of CX3CR1,
LS Mizoue, JF Bazan, EC Johnson, TM Handel - Biochemistry, 1999 - ACS Publications
Fractalkine, a novel CX3C chemokine, is unusual because of both its membrane-associated
structure and its direct role in cell adhesion. We have solved the solution structure of the …
structure and its direct role in cell adhesion. We have solved the solution structure of the …
CXC and CC chemokine receptors on coronary and brain endothelia
O Berger, X Gan, C Gujuluva, AR Burns, G Sulur… - Molecular …, 1999 - Springer
Background Chemokine receptors on leukocytes play a key role in inflammation and HIV-1
infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue …
infection. Chemokine receptors on endothelia may serve an important role in HIV-1 tissue …