Progressive wasting is common in many types of cancer and is one of the most important
factors leading to early death in cancer patients. Weight loss is a potent stimulus to food …

Neurotrophic factors are proteins which promote the survival of specific neuronal
populations. Many have other physiological effects on neurons such as inducing …

Cachexia is a common cause of morbidity and mortality in patients with advanced cancer. It
is characterised by numerous metabolic abnormalities including inefficient substrate …

Ciliary neurotrophic factor (CNTF) is a neurocytokine expressed in glial cells that acts on
brain cells to promote gene expression, survival, and differentiation. When administered …

Cardiotrophin-1 (CT-1), an IL-6–related cytokine, causes hypertrophy of cardiac myocytes
and has pleiotropic effects on various other cell types, including motoneurons. Here, we …

Ciliary neurotrophic factor (CNTF) has demonstrated therapeutic effects in several mouse
mutants with motoneuronal degeneration. However, the poor bioavailability and toxic side …

Neurotrophic factors are growth factors or cytokines that are inducible polypeptides and
permit intercellular communication. An explosion of information about neurotrophic factors is …

The aim of this study was to measure the body weight set point when rats are being handled
gently and thus experience emotional rise in body temperature. Wistar male rats were used …

Publisher Summary This chapter discusses several classes of nervous system growth
factors focusing on neurotrophic factors. In the peripheral nervous system (PNS) …

This is the second of two reviews in which we discuss the essential aspects of neurotrophic
factor neurobiology, the characteristics of each neurotrophic factor, and their clinical …