Positive selection of CD4+ T cells requires that the TCR of a developing thymocyte interact
with self MHC class II molecules on thymic cortical epithelium. In contrast, clonal deletion is …

Some MHC class II genes provide dominant resistance to certain autoimmune diseases via
mechanisms that remain unclear. We have shown that thymocytes bearing a highly …

A major question in end-stage T cell development is how T cell receptor (TCR) ligation on
immature CD4+ CD8+ double positive thymocytes is translated into either survival (positive …

Thymocytes are positively selected for αβ T cell antigen receptors (TCR) that recognize
antigen in conjunction with self-major histocompatibility complex (MHC) molecules. MHC …

The thymic medulla is a complex microenvironment which plays a crucial role in central
tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) …

The establishment of CD4+ T cell tolerance requires that self-reactive thymocytes are
negatively selected during thymic development. A threshold of antigen concentration …

Altered self peptides may drive T cell development by providing avidity of interactions low
enough to potentiate positive selection but not powerful enough to trigger programmed cell …

Positive selection has been proposed to be involved in protection from diabetes. We
examined positive selection by fluorescence-activated cell sorter analyses in thymocytes of …

The extent to which the indirect pathway of T cell recognition contributes to graft rejection
remains to be clarified, and this thesis examines its role in the antibody-mediated rejection of …

T lymphocytes are responsible for the recognition and clearance of infectious organisms.
They use a T cell receptor (TCR) that responds to foreign peptide antigens displayed by …