Cleidocranial dysplasia (CCD)(MIM 119600) is an autosomal dominant skeletal dysplasia
characterised by abnormal clavicles, patent sutures and fontanelles, supernumerary teeth …

Urist made the key discovery that demineralized bone fragments implanted either
subcutaneously or intramuscularly in animals induce bone formation (100, 101). The hunt for …

The mechanisms that control cell proliferation and cell differentiation during morphogenesis
of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) …

MT1-MMP is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating
pericellular proteolysis of extracellular matrix components. MT1-MMP is therefore thought to …

Mesenchymal stem cells (MSCs) residing in bone marrow (BM) are the progenitors for
osteoblasts and for several other cell types. In humans, the age‐related decrease in bone …

A series of subclonal cell lines with high or low differentiation/mineralization potential after
growth in the presence of ascorbic acid (AA) were derived from murine MC3T3‐E1 cells …

Both bone mass and serum leptin levels are increased in obesity. Because osteoblasts and
adipocytes arise from a common precursor in bone marrow, we assessed the effects of …

A protein module called the WW domain recognizes and binds to a short oligopeptide called
the PY motif, PPxY, to mediate protein–protein interactions. The PY motif is present in the …

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by
differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown …

Cbfa1, a transcription factor that belongs to the runt‐domain gene family, plays an essential
role in osteogenesis. Cbfa1‐deficient mice completely lacked both intramembranous and …