A cancer treatment is described in which im injection of plasmid DNA (pDNA) encoding
murine interferon α (mIFN-α) leads to potent antitumor effects on primary and metastatic …

Direct intratumoral (it) injection of adenoviruses (Ads) expressing specific
immunostimulatory cytokines represents an attractive strategy for the clinical implementation …

Dominant negative estrogen receptors are transcriptionally inactive, altered forms of the
estrogen receptor (ER) that can dimerize with the ER and have the potential to inactivate the …

Replication-competent adenoviruses (Ads) were used for oncolytic virotherapy soon after
they were discovered. Recently mutated and genetically engineered Ads have been shown …

The antitumor effect of the type I IFN, IFN-ω, was evaluated in both in vitro and in vivo studies
of human cancer. For these studies, the cDNA for human IFN-ω was cloned into a eukaryotic …

Studies of metastasis can be accelerated and provide more mechanistic information using
cell lines which reproducibly and aggressively metastasize, and which are accurately and …

A replication-deficient adenovirus encoding human interferon alpha 2b, driven by the human
cytomegalovirus (CMV) promoter, was constructed and characterized. This construct was …

In this study, we investigated the effects of human type I consensus interferon (IFN-
con1)(Amgen) gene transfer into body cavity-based lymphomas (BCBL)-1 cells, which are …

Human interferon-alpha (IFN-alpha) has been used in the management of leukemia, but its
diverse adverse effects may influence the ability of IFN-alpha to treat this disease. We …

UCSJYZPVAKXKNQ-HZYVHMACSA-N 1-[(1S, 2R, 3R, 4S, 5R, 6R)-3-carbamimidamido-6-
{[(2R, 3R, 4R, 5S)-3-{[(2S, 3S, 4S, 5R, 6S)-4, 5-dihydroxy-6-(hydroxymethyl)-3 …