▪ Abstract The hippocampus is a target of stress hormones, and it is an especially plastic and
vulnerable region of the brain. It also responds to gonadal, thyroid, and adrenal hormones …

Studies in animals showed that stress results in damage to the hippocampus, a brain area
involved in learning and memory, with associated memory deficits. The mechanism involves …

This study takes advantage of continuing advances in the precision of magnetic resonance
imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history …

Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and …

The relative contribution of genetic and environmental factors to the development of the
major psychiatric disorders has long been debated. Recently, considerable attention has …

Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or
neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing …

Adaptations at the cellular and molecular levels in response to stress and antidepressant
treatment could represent a form of neural plasticity that contributes to the pathophysiology …

By showing how and why human nature is what it is, evolutionary theory can help us see
better what we need to do to improve the human condition. Following evolutionary theory to …

There is increasing evidence for an association between the alteration of cytokine
concentrations in blood and the pathophysiology of depressive disorders. Studies in …

Background: Decreased hippocampal volume is observed in patients with Cushing's
syndrome and other conditions associated with elevated cortisol levels, stress, or both …