Cannabinoids have a long history of consumption for recreational and medical reasons. The
primary active constituent of the hemp plant Cannabis sativa is Δ9-tetrahydrocannabinol (Δ9 …

In 1975 tumor necrosis factor (TNF) was defined as an endotoxin-induced serum factor
which produced necrosis of tumors both in vitro and in vivo. 1 The original works on TNF …

Cannabinoids can modulate motor behaviour, learning and memory, cognition and pain
perception. These effects correlate with the expression of the cannabinoid receptor 1 (CB1) …

Δ9-Tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in preparations of
Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses …

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian
tissues. Although selective antagonists are available for each of the subtypes, most of the …

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633,
L759656 and AM630 - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide),
elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors …

We have examined the ligand regulation and G protein selectivity of the human cannabinoid
CB1 and CB2 receptors by an in situ reconstitution technique directly measuring G protein …

Cannabinoids modulate nociceptive processing through central and peripheral
mechanisms. The present study was conducted to evaluate axonal flow of cannabinoid …

In this study, we focused on the pharmacological characterization of cannabinoid receptor
coupling to G protein-gated inwardly rectifying potassium (GIRK) channels. Cannabinoids …