Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO),
iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is …

Findings in recent years strongly suggest that the stress-inducible gene heme oxygenase
(HO)-1 plays an important role in protection against oxidative stress. Although the …

Heme oxygenase-1 (HO-1) confers protection against a variety of oxidant-induced cell and
tissue injury. In this study, we examined whether exogenous administration of HO-1 by gene …

Heme oxygenase-1 (HO-1), an enzyme important in protection against oxidant stress, is
induced in human vascular endothelial cells by the cytokines tumor necrosis factor-α (TNF …

Rat fetal lung cells (RFL-6) were transiently transfected with a full-length rat heme
oxygenase (HO)-1 cDNA construct and then exposed to hyperoxia (95% O2-5% CO2) for 48 …

We have previously demonstrated that the lungs of mice can exhibit increased programmed
cell death or apoptosis after hyperoxic exposure in vivo. In this report, we show that …

Carbon monoxide is a product of haem degradation by haem oxygenase (HO), activated by
inflammatory cytokines and oxidants. This study examined whether allergen challenge can …

Objectives: Oxidative stress and inflammation induce the expression of heme oxygenase-1,
which produces carbon monoxide (CO), and nitric oxide synthase, which produces nitric …

Although the kidney represents a target for the accumulation and toxicity of arsenic, little is
known about the molecular targets of arsenic in this organ. Therefore, these studies were …

Haem oxygenase-1 (HO-1) is a highly inducible stress protein that removes haem from cells
with the release of biliverdin, carbon monoxide and low-molecular-mass iron (LMrFe) …