ContextGenetic testing for hereditary nonpolyposis colon cancer (HNPCC) is available, but
the rates of acceptance of testing or barriers to participation are not known. ObjectiveTo …

The discovery of genes responsible for inherited forms of colorectal cancer have the
potential to improve cancer risk assessment and counseling. Germline mutations (nonsense …

Genomic instability in its broadest sense is a feature of virtually all neoplas-tic cells. In
addition to the mutations and/or gene amplifications that appear to be a prerequisite for the …

The frequency, origin, and phenotypic expression of a germline MSH2 gene mutation
previously identified in seven kindreds with hereditary non-polyposis cancer syndrome …

Whilst individual planning of treatment and follow-up in every colorectal cancer case is an
increasing demand, prognostic markers are needed for predicting cancer progression in the …

Two apparently independent mechanisms of instability are recognized in colorectal cancer,
microsatellite instability and chromosomal instability. Evidence from colorectal cancer cell …

The breast cancer susceptibility genes, BRCA1 and BRCA2, differ in their contribution to
ovarian cancer. Recently, founder mutations in each of these genes were identified in …

Genomic instability has been proposed as a new mechanism of carcinogenesis involved in
hereditary non-polyposis colorectal cancer (HNPCC) and in a large number of sporadic …

Germline mutations that give rise to premature termination codons in mRNAs have
frequently been associated with aberrant processing of the nascent transcripts. This can take …

The multiple endocrine neoplasia (MEN) syndromes represent the entire field of
endocrinology, except for the diseases resulting from dysfunction of the gonadal endocrine …