The ability of cells to maintain genomic integrity is vital for cell survival and proliferation.
Lack of fidelity in DNA replication and maintenance can result in deleterious mutations …

Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for
the cellular transition from quiescence to the proliferative state. The ubiquitination and …

Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated
degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is …

Cyclin‐dependent kinases (CDKs) are essential for regulating key transitions in the cell
cycle, including initiation of DNA replication, mitosis and prevention of re‐replication. Here …

The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by
the ubiquitin–proteasome system. Activation of p27 degradation is seen in proliferating cells …

Centrosome duplication is a key requirement for bipolar spindle formation and correct
segregation of chromosomes during cell division. In a manner highly reminiscent of DNA …

Recent studies identified a short peptide motif that serves as a docking site for cyclin/cyclin-
dependent kinase (cdk) 2 complexes. Peptides containing this motif block the …

Activation of Cdc2, is the universal event controlling the onset of mitosis. In higher
eukaryotes, Cdc2 activity is in part regulated by inhibitory phosphorylation of Thr14 and …

We have identified six protein kinases that belong to the family of cdc2-related kinases in
Caenorhabditis elegans. Results from RNA interference experiments indicate that at least …

During the terminal differentiation of skeletal myoblasts, the activities of myogenic factors
regulate not only tissue-specific gene expressions but also the exit from the cell cycle. The …