B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Prolonged deprivation of food induces dramatic changes in mammalian metabolism,
including the release of large amounts of fatty acids from the adipose tissue, followed by …

▪ Abstract Dietary fat is an important macronutrient for the growth and development of all
organisms. In addition to its role as an energy source and its effects on membrane lipid …

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme
in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and …

The current United States Environmental Protection Agency (EPA) classification of di (2-
ethylhexyl) phthalate (DEHP) as a B2 “probable human” carcinogen is based on outdated …

Plasminogen activator inhibitor type-1 (PAI-1) is a major physiological inhibitor of
fibrinolysis, with its plasma levels correlating with the risk for myocardial infarction and …

Peroxisome proliferator‐activated receptors (PPARs) are ligand‐dependent transcription
factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and …

Adipocyte differentiation is regulated by at least two major transcription factors,
CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor …

Peroxisome proliferators (PPs) are chemicals of industrial and pharmaceutical importance
that elicit liver carcinogenesis by a non-genotoxic mechanism. One of the intriguing …