Synthetic nano‐scale fibrous extracellular matrix

PX Ma, R Zhang - … of Biomedical Materials Research: An Official …, 1999 - Wiley Online Library
Biodegradable polymers have been widely used as scaffolding materials to regenerate new
tissues. To mimic natural extracellular matrix architecture, a novel highly porous structure …

Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation

YS Nam, TG Park - … Materials Research: An Official Journal of …, 1999 - Wiley Online Library
Poly (l‐lactic acid) and its copolymers with d‐lactic and glycolic acid were used to fabricate
various porous biodegradable scaffolds suitable for tissue engineering and drug delivery …

Factors affecting the degradation rate of poly (lactide-co-glycolide) microspheres in vivo and in vitro

MA Tracy, KL Ward, L Firouzabadian, Y Wang, N Dong… - Biomaterials, 1999 - Elsevier
The purpose of this work was to study the degradation of poly (lactide-co-glycolide)(PLG)
microspheres in vivo and in vitro. Degradation rate constants were determined by measuring …

Perspectives on cell and collagen composites for tendon repair.

DL Butler, HA Awad - Clinical Orthopaedics and Related …, 1999 - journals.lww.com
Cell and matrix composites recently have been used to repair tendons and ligaments. In the
current study the authors briefly review prior studies in this area, and the contributions these …

Bone morphogenetic protein but not transforming growth factor-β enchances bone formation in canine diaphyseal nonunions implanted with a biodegradable …

JD Heckman, W Ehler, BP Brooks, TB Aufdemorte… - JBJS, 1999 - journals.lww.com
Background: The purpose of the present study was to create an effective bone-graft
substitute for the treatment of a diaphyseal nonunion. Methods: A standardized nonunion …

Tetracycline-HCl-loaded poly (DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: influence of γ-irradiation on radical formation and polymer …

B Bittner, K Mäder, C Kroll, HH Borchert… - Journal of Controlled …, 1999 - Elsevier
Tetracycline-HCl (TCH)-loaded microspheres were prepared from poly (lactide-co-
glycolide)(PLGA) by spray drying. The drug was incorporated in the polymer matrix either in …

In vitro and in vivo comparison of bulk and surface hydrolysis in absorbable polymer scaffolds for tissue engineering

KP Andriano, Y Tabata, Y Ikada… - Journal of Biomedical …, 1999 - Wiley Online Library
This article describes preliminary in vitro and in vivo studies comparing bulk and surface
hydrolysis in absorbable polymer scaffolds proposed for tissue engineering of bone. The two …

Treatment of severe orthopedic infections

WS Dernell - Veterinary clinics of north America: small animal …, 1999 - Elsevier
Severe infections are uncommon following orthopedic surgery, yet they can be frustrating for
the veterinarian and owner to treat and can result in devastating consequences for the …

Polymers with controlled physical state and bioerodibility

J Heller, SY Ng - US Patent 5,968,543, 1999 - Google Patents
R. Auerbach et al.,“S1te—spec1? c drug delivery to the lung”,[63] Continuation-in-part of
application No. 08/775,996, Jan. 3, Polymers fOrAdWmced Technologies) 3, 323_329 …

Mechanism of drug release from poly (L-lactic acid) matrix containing acidic or neutral drugs

M Miyajima, A Koshika, J Okada, M Ikeda - Journal of Controlled Release, 1999 - Elsevier
The release profiles of acidic and neutral drugs from poly (l-lactic acid)[P (L) LA] matrices
were investigated to reveal their release mechanism. Cylindrical matrices (rods; 10 mm× 1 …