Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

Appropriate subcellular localization is crucial for regulating p53 function. We show that p53
export is mediated by a highly conserved leucine-rich nuclear export signal (NES) located in …

p53 has a key role in the negative regulation of cell proliferation, in the maintenance of
genomic stability, and in the suppression of transformation and tumorigenesis. To identify …

The p73 gene is a structural and, in overexpression systems, functional p53 homologue.
Ectopic p73 expression can activate a broad subset of p53-responsive genes, induce …

Abstract p53 activation by diverse stresses involves post-translational modifications that alter
its structure and result in its nuclear accumulation. We will discuss several unresolved topics …

Abnormal p53 cellular localization has been considered to be one of the mechanisms that
could inactivate p53 function. To understand the regulation of p53 cellular trafficking, we …

Perturbation of p53 protein function is a common, if not universal, finding in human cancer.
Tumor suppression by p53 is due, at least in part, to its ability to activate transcription of …

Abundance and activity of p53 are predominantly regulated posttranslationally. Structural
disturbance in transcribed genes induced by radiation, eg DNA damage, or by …

The normal progression of cells through the cell cycle requires a fine balance between the
functions of positive and negative regulatory factors. In response to various stresses …