Weight loss in elderly patients is a common clinical problem. Wasting and cachexia are
associated with severe physiologic, psychologic, and immunologic consequences …

Immune function declines with age, leading to increased infection and cancer rates in aged
individuals. In fact, recent progress in the study of immune ageing has introduced the idea …

Background. Inflammatory mechanisms and immune activation have been hypothesized to
play a role in the pathogenesis of age-associated diseases such as dementia and …

Introduction‐We propose that the increase in TNF‐α and IL‐6 in the brain in idiopathic
parkinsonism is in response to a peripheral immune/inflammatory process, so ubiquitous as …

Ageing is associated with decreased resistance to bacterial infections and concomitant
increased circulating levels of inflammatory cytokines. The purpose of the present study was …

Aging is associated with impairment of immune functions. Age-dependent alterations in T-
cells are well known. Although the pivotal role of monocytes in immune regulation by their …

Dysregulation of IL‐6 synthesis is thought to play a role in the development of a number of
age‐related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis …

Background—Recently it has been reported that activation of the inflammatory response
system (IRS) may play a role in the aging process and in the pathogenesis of the …

Physiologic systems have substantial reserves in younger individuals. The process of aging
and intercurrent pathologic processes gradually eliminate these reserves. Changes in …

In essence, the immune system is enhanced during moderate and severe exercise, and only
intense long-duration exercise is followed by impairment of the immune system. The latter …