All research on schizophrenia depends on selecting the correct phenotype to define the
sample to be studied. Definition of the phenotype is complicated by the fact that there are no …

The history of psychiatric research is filled with widely accepted etiologic and
pathophysiologic theories that eventually were proven wrong. The prevailing …

OBJECTIVE: Subtle behavioral and intellectual abnormalities are often present in apparently
healthy adolescents who later develop schizophrenia. The authors investigated whether …

The natural history of schizophrenia is often chronic and debilitating, an enduring fact that
draws attention to the first episode and early course of the disorder when neurobiological …

OBJECTIVE: Whether cognitive function in schizophrenia deteriorates, improves, or remains
stable is a crucial question. Few studies have examined the longitudinal stability of cognitive …

Several epidemiological studies have reported an association between complications of
pregnancy and delivery and schizophrenia, but none have had sufficient power to examine …

Schizophrenia is likely to be caused by several susceptibility genes and may have
environmental factors that interact with susceptibility genes and/or nongenetic causes …

Background Adolescence provides a window to examine regional and disease-specific late
abnormal brain development in schizophrenia. Because previous data showed progressive …

Background We examined whether children who are diagnosed as having schizophrenia in
adulthood could be distinguished from their peers on performance in elementary school …

Background Schizophrenia is a multifactorial disorder that is associated with disturbed
cerebral development. Structural brain-imaging studies have consistently shown that the …