Basic and translational research achievements over the past 2 decades have disclosed the
molecular mechanisms underlying several genetic forms of hypopituitarism. Disorders that …

During fetal development of the anterior pituitary gland, a number of sequential processes
occur that effect cell differentiation and proliferation. Molecular anlyses have revealed …

Genomic DNA from 18 patients with combined pituitary hormone deficiency was screened
for 2-bp deletion (A301, G302) in PROP1 gene by Bcg I restriction endonuclease analysis of …

We have investigated the largest family with PROP1 deficiency reported to date. Eight
patients, aged 17–40 yr, in two sibships with possibly related mothers but no parental …

Hereditary dwarfism was first recognized in inhabitants of the island of Krk in the Adriatic in
1864. Since then 24 related dwarfs have been recorded. Their pedigrees and heights are …

Humans with hypogonadotropic hypogonadism (HH) manifest irreversible pubertal delay,
infertility, and low serum levels of follicle‐stimulating hormone (FSH) and luteinizing …

Prophet of Pit-1 (Prop-1), which is a paired-like homeodomain transcription factor, is capable
of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression …

Mutations in the pituitary-specificpaired-like homeodomain transcription factor PROP-1
result in combined pituitary hormone deficiency (CPHD) which includes all anterior pituitary …

This review will address contributions of nuclear transcription factors to the embryologic
development and definitive function of the anterior pituitary gland. The HESX1, PITX1 …

Patients with hypogonadotropic hypogonadism (HH) present with delayed puberty, infertility,
and low serum gonadotropins. The molecular basis for most cases of HH is unknown, but …