Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Genetic approaches have succeeded in defining the molecular basis of an increasing array
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes …
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes …
Dysfunction of Delayed Rectifier Potassium Channels in an Inherited Cardiac Arrhythmia
MC Sanguinetti - Annals of the New York Academy of Sciences, 1999 - Wiley Online Library
The rapid (lKr) and slow (IKs) delayed rectifier K+ currents are key regulators of cardiac
repolarization. HERG encodes the Kr channel, and KVLQT1 and hminK encode subunits …
repolarization. HERG encodes the Kr channel, and KVLQT1 and hminK encode subunits …
Replacement by Homologous Recombination of the minK Gene With lacZ Reveals Restriction of minK Expression to the Mouse Cardiac Conduction System
S Kupershmidt, T Yang, ME Anderson… - Circulation …, 1999 - Am Heart Assoc
The minK gene encodes a 129-amino acid peptide the expression of which modulates
function of cardiac delayed rectifier currents (I Kr and I Ks), and mutations in minK are now …
function of cardiac delayed rectifier currents (I Kr and I Ks), and mutations in minK are now …
Rapid Delayed K+ Current and Quinidine Sensitivity are Reduced in Healed Myocardial Infarction.
E Carmeliet - Journal of Cardiovascular Electrophysiology, 1999 - search.ebscohost.com
Examines the cellular electrophysiologic aspects and the accompanying changes in ionic
currents of subacute or healing myocardial infarction. Action potential duration at …
currents of subacute or healing myocardial infarction. Action potential duration at …
Delayed rectifier potassium channels in normal and abnormal cardiac repolarization
MC Sanguinetti, M Tristani-Firouzi - Current topics in membranes, 1999 - Elsevier
Publisher Summary The delayed rectifier K+ current (IK) of ventricular myocytes is
composed of three distinct currents that can be distinguished based on their rate of …
composed of three distinct currents that can be distinguished based on their rate of …