Drug abuse and dependence define behavioral states involving increased allocation of
behavior towards drug seeking and taking at the expense of more appropriate behavioral …

Our knowledge of the organization of the nucleus accumbens has been greatly advanced in
the last two decades, but only now are we beginning to understand the complex neural …

Repeated treatment with psychostimulant drugs produces changes in brain and behaviour
that far outlast their initial neuropharmacological actions. The nature of persistent drug …

To assess behavioral experience effects on synaptic plasticity after brain damage, the
present study examined the effects of complex motor skills training (the acrobatic task) on …

The mesolimbic dopamine (DA) system has been implicated in drug reward, locomotor
sensitization, and responding for reward-related stimuli [termed conditioned reinforcers …

Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed
for 24–25 days before their brains were processed for Golgi‐Cox staining. Prior exposure to …

Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization
and associated neuroadaptations. Although sensitization induced by a single …

Amphetamine analogs have emerged as popular recreational drugs of abuse. The number
of reports of these substances producing severe acute toxicity and death is increasing. In …

These experiments were designed to assess the role of neurotrophins and the Ras/mitogen-
activated protein kinase (MAP) signal transduction cascade in behavioral sensitization to …

Regional differences in dextroamphetamine (AMPH)-induced dopamine (DA) release in the
baboon striatum were assessed using positron emission tomographic (PET) measures of …