▪ Abstract Transcription in eukaryotes is frequently regulated by a mechanism termed
combinatorial control, whereby several different proteins must bind DNA in concert to …

Aristaless-related genes, a subset of the Paired-related homeobox genes, have in the past
few years emerged as a group of regulators of essential events during vertebrate …

We analyzed the atomic models of 75 X-ray structures of protein− nucleic acid complexes
with the aim of uncovering common properties. The interface area measured the extent of …

Hox homeodomain proteins are developmental regulators that determine body plan in a
variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers …

Regulatory proteins play a critical role in controlling complex spatial and temporal patterns
of gene expression in higher organism, by recognizing multiple DNA sequences and …

The genes belonging to the Paired class exert primary developmental functions. They are
characterized by six invariant amino acid residues in the homeodomain, while the residue at …

Previous work has established that the melanocyte-specific tyrosinase-related protein-1
(TRP-1) promoter is regulated positively by the microphthalmia-associated transcription …

Alx4 and Cart1 are closely related members of the family of transcription factors that contain
the paired-type homeodomain. In contrast to other types of homeodomains, the paired-type …

The transcription factor Pax6 is required for normal development of the central nervous
system, the eyes, nose, and pancreas. Here we show that the transactivation domain (TAD) …

The chimeric transcription factor Pax3-FKHR, produced by the t (2; 13)(q35; q14)
chromosomal translocation in alveolar rhabdomyosarcoma, consists of the two Pax3 DNA …