We hypothesized that age-linked changes in the composition and elastic properties of the
arterial wall occur earlier in hypertensive than in normotensive rats. We evaluated the …

Objective To study the alteration in the biomechanical properties of the thoracic aorta and its
composition in young normotensive Wistar-Kyoto (WKY) rats, spontaneously hypertensive …

Reducing pulse pressure might be more powerful than reducing mean arterial pressure to
obtain regression of vascular hypertrophy. However, this hypothesis has never been …

The effect of antihypertensive treatment on the development of large-artery remodeling in
young animals has been widely studied, but reversal of established changes in older …

Objectives. The aim of this study was to characterize fully in vivo aortic compliance over a
wide range of passive distending pressures, and to study pharmacologically induced …

Neuropeptide Y (NPY) is a key modulator of the autonomic nervous system playing pivotal
roles in cardiovascular and neuronal functions. In this study, we assessed the cellular …

Systemic arterial elastic properties, important determinants of left ventricular function and
coronary blood flow, are compromised in myocardial infarction (MI). The cardiac effect of …

Vascular hypertrophy is considered to be an adaptive response to increased arterial wall
stress in hypertension. Although there are several reports concerning the effect of …

Objective To distinguish between static (due to slow changes in pressure) and dynamic (due
to pressure pulsatility) components of aortic compliance over a large pressure range in vivo …

The aorta and large arteries are generally thought of as conduit vessels whose main
function is to provide a conduit for blood fiow to reach the peripheral tissues. However …