The neurobiology of cannabinoid analgesia

JM Walker, AG Hohmann, WJ Martin, NM Strangman… - Life sciences, 1999 - Elsevier
The discovery of cannabinoid receptors and their putative endogenous ligands raises
questions as to the nature of the effects produced by cannabinoids on neural circuits that …

Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study

AG Hohmann, M Herkenham - Neuroscience, 1999 - Elsevier
In situ hybridization histochemistry was used to show the distribution of messenger RNA for
central cannabinoid CB1 receptors in dorsal root ganglia of the rat. CB1 messenger RNA …

Cannabinoid receptors undergo axonal flow in sensory nerves

AG Hohmann, M Herkenham - Neuroscience, 1999 - Elsevier
Cannabinoids modulate nociceptive processing through central and peripheral
mechanisms. The present study was conducted to evaluate axonal flow of cannabinoid …

Pre-and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord

AG Hohmann, EM Briley, M Herkenham - Brain research, 1999 - Elsevier
In vitro receptor binding and quantitative autoradiography were used to assess the pre-and
postsynaptic distribution of cannabinoid receptors in the cervical dorsal horn of the rat spinal …

Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections

WJ Martin, PO Coffin, E Attias, M Balinsky, K Tsou… - Brain research, 1999 - Elsevier
Cannabinoids suppress behavioral and neurophysiological responses to noxious stimuli in
rodents when administered systemically. The purpose of this study was to extend previous …

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation

WJ Martin, CM Loo, AI Basbaum - Pain, 1999 - journals.lww.com
Cannabinoid receptor (CB1) agonists strongly inhibit behavioral responses to acute noxious
stimuli, but their effects on behavioral responses in persistent pain states are less clear …

Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat

AG Hohmann, K Tsou… - Journal of …, 1999 - journals.physiology.org
Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in
the lumbar dorsal horn of the rat. The effects of cannabinoid agonists on noxious heat …

Cannabinoid WIN 55,212-2 inhibits the activity-dependent facilitation of spinal nociceptive responses

NM Strangman, JM Walker - Journal of neurophysiology, 1999 - journals.physiology.org
Cannabinoids suppress nociceptive processing of acute stimuli, but little is known about
their effects on processes that lead to hyperexcitability of nociceptive neurons following …

[PDF][PDF] Basic mechanisms of cannabinoid-induced analgesia

WJ Martin - IASP newsletter, 1999 - iowamedicalmarijuana.org
The identification of cannabinoid receptors and the discovery of endogenous cannabinoids
ushered in a new era of research on the biological effects of cannabis-like compounds …