Hypermethylation of tumor suppressor genes and other genes functionally important in the
neoplastic process is a recently recognized process. This epigenetic process is …

Lung cancer is the largest cancer killer of men and women in the united states. In addition to
the progress made from antismoking primary prevention measures, new tools to help treat …

Tissue inhibitor of metalloproteinase-3 (TIMP-3) antagonizes matrix metalloproteinase
activity and can suppress tumor growth, angiogenesis, invasion, and metastasis. Loss of …

It has recently been suggested that silencing of the hMLH1 gene by promoter
hypermethylation is the mechanism underlying the presence of the microsatellite instability …

Death-associated protein kinase (DAP-Kinase) is a novel serine/threonine kinase whose
expression is required for γ interferon-induced apoptosis. A previous study suggested that …

Abstract he p73 gene is located on 1p36. 2-3, a region that is frequently deleted in human
cancer. Because p73 encodes for a protein that is both structurally and functionally …

Mycosis fungoides is a low-grade cutaneous T-cell lymphoma. Early treatment often involves
the use of topical chemotherapy such as mechlorethamine or carmustine although single …

The mechanisms by which cells regulate gene expression are often altered in tumors.
Modulating aspects of the components responsible for the nuclear packaging of DNA is one …

Carcinoma of the urinary bladder is the most common malignancy among Egyptian males,
accounting for 40% of total cancer incidence, while in females it ranks second only to breast …