Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

Background—Endothelial dysfunction is associated with atherosclerosis and may contribute
to ischemic syndromes. We assessed the contribution of endothelium-derived nitric oxide …

Since its discovery over 20 years ago as an intercellular messenger, nitric oxide (NO), has
been extensively studied with regard to its involvement in the control of the circulation and …

When exercise in the presence of a coronary artery stenosis results in subendocardial
ischemia, administration of a nitric oxide (NO) donor increases subendocardial blood flow …

Background. N6-Cyclopentyladenosine (CPA), a structural analog of adenosine, is a
vasodilator with extensive pharmacological effects. However, little is known about the effect …

Coronary perfusion pressure, Pp, affects coronary arterial resistance, Ra,(autoregulation) as
well as myocardial oxygen consumption, MV o2 (Gregg's phenomenon). The interaction …

For over 50 years, it has been recognized that coronary blood flow is precisely matched to
cardiac metabolism. The interactions which govern this matching remain unknown. In the …

Objective: Hypercholesterolemia has been shown to impair endothelium-mediated, nitric
oxide (NO)-dependent responses to acetylcholine (ACh), serotonin, substance P and flow …

Several investigators studied whether the endothelial release of nitric oxide (NO)
deteriorates in patients with coronary spastic angina; however, the answer to this important …

For over 50 years, it has been recognized that coronary blood flow is precisely matched to
cardiac metabolism. The interactions which govern this matching remain unknown. In the …