Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes

JR Lindner, J Song, F Xu, AL Klibanov, K Singbartl… - Circulation, 2000 - Am Heart Assoc
Background—Lipid microbubbles used for perfusion imaging with ultrasound are retained
within inflamed tissue because of complement-mediated attachment to leukocytes within …

Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin-and complement-mediated adherence to activated …

JR Lindner, MP Coggins, S Kaul, AL Klibanov… - Circulation, 2000 - Am Heart Assoc
Background—Albumin microbubbles that are used for contrast echocardiography persist
within the myocardial microcirculation after ischemia/reperfusion (IR). The mechanism …

Liposomal formulations of anticancer drugs: selectivity and effectiveness

U Massing, S Fuxius - Drug resistance updates, 2000 - Elsevier
After a delay of roughly 30 years, liposomes are becoming important as drug-targeting
systems especially in anticancer therapy. Two liposomal anthracycline formulations are now …

Immobilized lipid-bilayer materials

DY Sasaki, DA Loy, SA Yamanaka - US Patent 6,048,546, 2000 - Google Patents
[57] ABSTRACT A method for preparing encapsulated lipid-bilayer materials in a silica
matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and …

Enhanced anti-inflammatory activity of a liposomal intercellular adhesion molecule-1 antisense oligodeoxynucleotide in an acute model of contact hypersensitivity

SK Klimuk, SC Semple, PN Nahirney, MC Mullen… - … of Pharmacology and …, 2000 - ASPET
The anti-inflammatory activity of free and liposome-encapsulated oligonucleotide targeted
against intercellular adhesion molecule-1 mRNA was investigated in a delayed type …

Chemical degradation of liposomes by serum components detected by NMR

M Foradada, MD Pujol, J Bermúdez… - Chemistry and physics of …, 2000 - Elsevier
Interaction between serum components and liposomes is an oxygen-dependent exothermic
process. We studied the interaction of 100 nm extruded liposomes (bearing positive …

Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their relationship

T Ishida, H Kojima, H Harashima, H Kiwada - International journal of …, 2000 - Elsevier
The biodistribution of liposomes with two different kind phospholipids (hydrogenated egg
phosphatidylcholine and egg phosphatidylcholine) plus cholesterol (CHOL) were …

Serum albumin–lipid membrane interaction influencing the uptake of porphyrins

R Galántai, I Bárdos-Nagy, K Módos, J Kardos… - Archives of Biochemistry …, 2000 - Elsevier
It is frequently observed in pharmaceutical practice that entrapped substances are lost
rapidly when liposomes are used as carriers to introduce substances into cells. The reason …

[图书][B] Sensitive detection and prevention of protein adsorption on biomaterial (lipid bilayer) surfaces

Z Xu - 2000 - search.proquest.com
The adsorption of proteins on biomaterial surfaces is recognized as the first and the most
important event that determines or directs consequent host responses. The amount …