Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …

Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar
compounds that induce growth arrest in transformed cells and show promise for the …

Epigenetic mechanisms are involved in regulating chromatin structure and gene expression
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …

Background Neuroblastoma is a common childhood cancer with a poor overall prognosis.
Retinoic acids (RAs) have been studied as a potential therapy, showing promise in recurrent …

Histone deacetylases are promising targets for cancer treatment. Here we studied the in vitro
effects of a potent histone deacetylase inhibitor, FK228 (formerly FR901228), on human …

In cells, genes are contained within chromatin—a highly structured array of DNA wrapped
around core histone proteins. Packaged genes are subject to a variety of regulatory …