Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells
PA Marks, VM Richon, RA Rifkind - Journal of the National …, 2000 - academic.oup.com
Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
VM Richon, TW Sandhoff… - Proceedings of the …, 2000 - National Acad Sciences
Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal
lysine residues of core nucleosomal histones. This activity is associated generally with …
lysine residues of core nucleosomal histones. This activity is associated generally with …
Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Suppresses the Growth of Prostate Cancer Cells in Vitro and in Vivo
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar
compounds that induce growth arrest in transformed cells and show promise for the …
compounds that induce growth arrest in transformed cells and show promise for the …
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors
WJ Magner, AL Kazim, C Stewart… - The Journal of …, 2000 - journals.aai.org
Epigenetic mechanisms are involved in regulating chromatin structure and gene expression
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …
through repression. In this study, we show that histone deacetylase inhibitors (DAIs) that …
Histone deacetylase inhibitors and retinoic acids inhibit growth of human neuroblastoma in vitro
DC Coffey, MC Kutko, RD Glick… - … : The Official Journal …, 2000 - Wiley Online Library
Background Neuroblastoma is a common childhood cancer with a poor overall prognosis.
Retinoic acids (RAs) have been studied as a potential therapy, showing promise in recurrent …
Retinoic acids (RAs) have been studied as a potential therapy, showing promise in recurrent …
Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells
M Murata, M Towatari, H Kosugi… - Japanese journal of …, 2000 - Wiley Online Library
Histone deacetylases are promising targets for cancer treatment. Here we studied the in vitro
effects of a potent histone deacetylase inhibitor, FK228 (formerly FR901228), on human …
effects of a potent histone deacetylase inhibitor, FK228 (formerly FR901228), on human …
Chromatin-immune connections: regulation of MHC and other genes
WJ Magner, TB Tomasi - Journal of reproductive immunology, 2000 - Elsevier
In cells, genes are contained within chromatin—a highly structured array of DNA wrapped
around core histone proteins. Packaged genes are subject to a variety of regulatory …
around core histone proteins. Packaged genes are subject to a variety of regulatory …