The regulation of cell growth and survival can be subverted by a variety of genetic defects
that alter transcriptional programs normally responsible for controlling cell number. High …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …

The Wnt family of secreted signalling molecules are essential in embryo development and
tumour formation. The Frizzled (Fz) family of serpentine receptors function as Wnt …

The long bones of the developing skeleton, such as those of the limb, arise from the process
of endochondral ossification, where cartilage serves as the initial anlage element and is …

The Wnt family of secreted molecules functions in cell-fate determination and
morphogenesis during development in both vertebrates and invertebrates (reviewed in ref.) …

E-cadherin and the associated catenin complex have been recognised as performing a key
role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to …

Secreted Frizzled-related protein-1 (sFRP-1) contains a cysteine-rich domain homologous to
the putative Wnt-binding site of Frizzleds. To facilitate the biochemical and biological …

Long bones of the appendicular skeleton are formed from a cartilage template in a process
known as endochondral bone development. Chondrocytes within this template undergo a …

Regulation of β-catenin degradation by intracellular components of the wnt pathway was
reconstituted in cytoplasmic extracts of Xenopus eggs and embryos. The ubiquitin …

Syndecan-1 is a cell-surface, heparan-sulphate proteoglycan (HSPG) predominantly
expressed by epithelial cells. It binds specifically to many proteins, including oncoproteins …