Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

DNA methylation is associated with the silencing of gene expression. The predominant
mechanism involves the methylation of DNA and the subsequent recruitment of binding …

The Insulin-like growth factor 2 (Igf2) and H19 genes are imprinted, resulting in silencing of
the maternal and paternal alleles, respectively. This event is dependent upon an imprinted …

Advanced hormone-independent prostate cancer is characterized by a significant loss of
androgen receptor (AR) expression in 20–30% of the tumors. The transcriptional block …

Ligand screening was utilized to isolate a human cDNA that encodes a novel CpG binding
protein, human CpG binding protein (hCGBP). This factor contains three cysteine-rich …

The imprinted mouse gene Gnas produces the G protein α-subunit GSα and several other
gene products by using alternative promoters and first exons. GSα is maternally expressed …

The introduction of intracytoplasmic sperm injection (ICSI) has raised concern about safety
in terms of a possible increase in the incidence of major congenital malformations …

Glutathione S-transferases, enzymes that defend cells against damage mediated by oxidant
and electrophilic carcinogens, may be critical determinants of cancer pathogenesis. We …

The olfactory receptor (OR) gene cluster on human chromosome 17p13. 3 was subjected to
mixed shotgun automated DNA sequencing. The resulting 412 kb of genomic sequence …

The mechanisms that establish DNA methylation in eukaryotes are poorly understood. In
principle, methylation in a particular chromosomal region may reflect the presence of a …