The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis
DC Chung - Gastroenterology, 2000 - Elsevier
The impact that modern molecular biology has had on elucidating the genetic basis of
neoplasia is best illustrated by the paradigm of colon cancer. Several unique features of …
neoplasia is best illustrated by the paradigm of colon cancer. Several unique features of …
DNA mismatch repair genes and colorectal cancer
JMD Wheeler, WF Bodmer, NJMC Mortensen - Gut, 2000 - gut.bmj.com
Positional cloning and linkage analysis have shown that inactivation of one of the mismatch
repair genes (hMLH1, hMSH2, hPMS1, hPMS2, GTBP/hMSH6) is responsible for the …
repair genes (hMLH1, hMSH2, hPMS1, hPMS2, GTBP/hMSH6) is responsible for the …
Sporadic colorectal adenocarcinomas with high‐frequency microsatellite instability: Pathobiologic features, hMLH1 and hMSH2 expression, and clinical outcome
BACKGROUND Widespread microsatellite instability (MSI) occurs in nearly 15% of sporadic
colorectal cancers. Large bowel carcinomas with high‐frequency MSI (MSI‐H)(instability …
colorectal cancers. Large bowel carcinomas with high‐frequency MSI (MSI‐H)(instability …
Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum
JR Jass, H Iino, A Ruszkiewicz, D Painter, MJ Solomon… - Gut, 2000 - gut.bmj.com
AIM Colorectal cancer has been described in association with hyperplastic polyposis but the
mechanism underlying this observation is unknown. The aim of this study was to …
mechanism underlying this observation is unknown. The aim of this study was to …
PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases
E Bussaglia, E Del Rio, X Matias-Guiu, J Prat - Human pathology, 2000 - Elsevier
PTEN mutations have been reported to be frequent in endometrioid carcinomas of the
endometrium (EEC). Some correlation has been found between PTEN mutations and the …
endometrium (EEC). Some correlation has been found between PTEN mutations and the …
Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients
WJF de Leeuw, JW Dierssen, HFA Vasen… - The Journal of …, 2000 - Wiley Online Library
Instability of microsatellite repeat sequences has been observed in colorectal carcinomas
and in extracolonic malignancies, predominantly endometrial tumours, occurring in the …
and in extracolonic malignancies, predominantly endometrial tumours, occurring in the …
DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer
H Iino, L Simms, J Young, J Arnold, IM Winship… - Gut, 2000 - gut.bmj.com
BACKGROUND AND AIM Hereditary non-polyposis colorectal cancer (HNPCC), as its name
implies, is associated with few adenomas, and the early evolution of colorectal neoplasia is …
implies, is associated with few adenomas, and the early evolution of colorectal neoplasia is …
Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis
RB Chadwick, GL Jiang… - Proceedings of the …, 2000 - National Acad Sciences
The distal portion of chromosome 1p is one of the most commonly affected regions in human
cancer. In this study of hereditary and sporadic colorectal cancer, a region of frequent …
cancer. In this study of hereditary and sporadic colorectal cancer, a region of frequent …
Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma
W Habano, T Sugai, SI Nakamura, N Uesugi… - Gastroenterology, 2000 - Elsevier
Background & Aims: Microsatellite instability (MSI) in mitochondrial DNA (mtDNA) is
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI …
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI …
M6P/IGF2R is mutated in squamous cell carcinoma of the lung
FM Kong, MS Anscher, MK Washington, JK Killian… - Oncogene, 2000 - nature.com
In addition to the intracellular sorting of lysosomal enzymes, the mannose 6-
phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a critical role in regulating …
phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a critical role in regulating …