Neuronal apoptosis sculpts the developing brain and has a potentially important role in
neurodegenerative diseases. The principal molecular components of the apoptosis …

Explosive advances in biological knowledge are often triggered by episodes of conceptual
convergence—moments when scientists working on different experimental systems realize …

Oxidative balance is emerging as an important issue in understanding the pathogenesis of
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …

Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a
transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6 …

Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with
presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

Cleavage of amyloid precursor protein (APP) by the β-and γ-secretases generates the
amino and carboxy termini, respectively, of the Aβ amyloidogenic peptides Aβ40 and Aβ42 …

Potassium channels play important roles in vital cellular signaling processes in both
excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have …

Abstract “If it were not for the great variability among individuals medicine might as well be a
science and not an art.” The thoughts of Sir William Osler in 1892 reflect the view of …