Previous lines of evidence have shown that inhibition of DNA methyltransferase (MeTase)
can arrest tumor cell growth; however, the mechanisms involved were not clear. In this …

Pharmacology and therapeutics have traditionally focused on altering the activity of specific
proteins that play an important physiological role either to counteract disease processes or …

Changes in cytosine methylation are known to occur in response to various environmental
stimuli, therefore, we looked at methylation changes in relation to stem elongation. More …

The mouse insulin-like growth factor II receptor (Igf2r) gene encodes two reciprocally
imprinted RNA transcripts: paternally imprinted Igf2r sense and maternally imprinted Igf2r …

Global hypomethylation of genes and repetitive sequences, as well as hypermethylation of
certain genes known to be involved in tumor suppression, are observed concurrently in …

The biological significance of cytosine methylation is as yet incompletely understood, but
substantial and growing evidence strongly suggests that perturbation of methylation …

Kohlenstoff-6 angreift und so ein kovalentes DNA-Protein-Intermediat bildet. Die Addition
des Nukleophils aktiviert das Kohlenstoff-5 des Pyrimidinringes und ermöglicht so den …