T cell memory depends on factors that regulate expansion and death of these cells after
antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased …

ABSTRACT CD4+ T-helper type 1 (Th1) responses are essential for the resolution of a
primary Chlamydia trachomatis genital tract infection; however, elements of the immune …

CD8+ T lymphocytes are important mediators of adaptive immunity against certain viral,
protozoan and bacterial pathogens. Activated CD8+ T cells are able to induce cytolysis of …

Abstract Single Ag-specific CD8+ T cells from IFN-γ-deficient (GKO) or perforin-deficient
(PKO) mice provide substantial immunity against murine infection with Listeria …

Although they are known for their capacity to kill infected cells, Ag-specific CD8+ T cells
elaborate other effector mechanisms, including TNF and IFN-γ, that contribute to defense …

The mechanisms by which CD8+ T cells mediate immunity against bacterial pathogens
remain largely unknown. Perforin-dependent cytolysis plays a role, but is not required for …

Thee research described in this thesis was was performed as part of the Amsterdam Cohortt
Studies on HIV-1 infection and AIDS and was conducted at the department off Clinical Viro …