Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice
K Yao, ES Lee, DJ Bentrem, G England… - Clinical Cancer …, 2000 - AACR
The estrogen receptor (ER)-positive MCF-7 breast cancer cell line can be transplanted into
athymic mice and grown into tumors with estradiol (E2) support. Tamoxifen (TAM) blocks E2 …
athymic mice and grown into tumors with estradiol (E2) support. Tamoxifen (TAM) blocks E2 …
Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351
JMG Schafer, H Liu, DJ Bentrem, JW Zapf, VC Jordan - Cancer Research, 2000 - AACR
The active metabolite of tamoxifen, 4-hydroxytamoxifen (4-OHT), is used in the laboratory for
mechanistic studies of antiestrogen action. This compound binds to the estrogen receptor α …
mechanistic studies of antiestrogen action. This compound binds to the estrogen receptor α …
Pure anti-oestrogens
C Hermenegildo, A Cano - Human reproduction update, 2000 - academic.oup.com
Pure anti-oestrogens are a group of at least five new compounds which are able to
antagonize the effects of oestrogen in all tissues and species studied. The mechanism by …
antagonize the effects of oestrogen in all tissues and species studied. The mechanism by …
Novel agents to modulate oestrogen action
As women enter the menopause, the majority suffers symptoms associated with a dramatic
fall in circulating levels of 17β-oestradiol and oestrone. As a result, the iestrogen protective …
fall in circulating levels of 17β-oestradiol and oestrone. As a result, the iestrogen protective …
Estrogen action and breast cancer
H Liu, VC Jordan - Principles of Molecular Oncology, 2000 - Springer
Worldwide, breast cancer is the most common cancer affecting women, accounting for 19%
of all malignancies in women (1). The growth of breast tumors can be regulated by multiple …
of all malignancies in women (1). The growth of breast tumors can be regulated by multiple …
[图书][B] A human prolactin receptor antagonist, hPRL-G129R, inhibits breast cancer cell proliferation through induction of apoptosis
P Ramamoorthy - 2000 - search.proquest.com
Human breast cancer is the predominant malignancy and the leading cause of cancer death
in women from Western society. The cause of breast cancer is still unknown. Recently, the …
in women from Western society. The cause of breast cancer is still unknown. Recently, the …