Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is a major
determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays a …

Background: The role of protein phosphorylation in the Pasteur effect—the phenomenon
whereby anaerobic conditions stimulate glycolysis—has not been addressed. The AMP …

The AMP-activated protein kinase (AMPK) cascade plays an important role in the regulation
of energy homeostasis within the cell. AMPK is a heterotrimer composed of a catalytic …

Insulin regulates the rate of expression of many hepatic genes, including PEPCK, glucose-6-
phosphatase (G6Pase), and glucose-6-phosphate dehydrogenase (G6PDHase). The …

In the liver, glucose induces the expression of a number of genes involved in glucose and
lipid metabolism, eg, those encoding L-type pyruvate kinase and fatty acid synthase. Recent …

The AMP-activated protein kinase (AMPK) is the central component of a protein kinase
cascade that is activated by cellular stresses causing ATP depletion and has been referred …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-gated Cl–
channel that regulates other epithelial transport proteins by uncharacterized mechanisms …

In cells expressing only the Glut1 isoform of glucose transporters, we have shown that
glucose transport is markedly stimulated in response to hypoxia or inhibition of oxidative …

Abstract Despite 14‐3‐3 proteins being implicated in the control of the eukaryotic cell cycle,
metabolism, cell signalling and survival, little is known about the global regulation or …

Uncoupling protein 3 (UCP-3), a member of the mitochondrial transporter superfamily, is
expressed primarily in skeletal muscle where it may play a role in altering metabolic function …