To examine whether this defect in glucose transport or hexokinase II activity was a primary
defect or an acquired defect secondary to other factors, such as glucose toxicity (19), we …

Plasma free fatty acids (FFA) might mediate the insulin resistance and impaired glucose
tolerance associated with central obesity. Central adipocytes are resistant to insulin …

The prevalence of type 2 diabetes mellitus is growing worldwide. By the year 2020, 250
million people will be afflicted 1. Most forms of type 2 diabetes are polygenic with complex …

Retroviral protease inhibitors used as therapy for HIV-1 infection have been causally
associated with serious metabolic side effects, including peripheral lipodystrophy …

The pivotal role in vivo of insulin is to control fuel homeostasis. Insulin exerts its effect on
three main target tissues: liver, fat and skeletal muscle. Resistance to the normal action of …

Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may be
related to alterations in fat metabolism. Fatless mice have been created using dominant …

Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis
of type 2 diabetes. Mice with muscle-specific inactivation of the insulin receptor gene …

To determine whether uncoupling respiration from oxidative phosphorylation in skeletal
muscle is a suitable treatment for obesity and type 2 diabetes, we generated transgenic mice …

The maintenance of normal carbohydrate metabolism requires an intricate interplay
between insulin action and insulin secretion. Type 2 diabetes usually results from a …

At least eight distinct pathophysiologic abnormalities have been associated with type 2
diabetes mellitus (T2DM). It is well established that decreased peripheral glucose uptake …