Important aspects of cell cycle regulation are the checkpoints, which respond to a variety of
cellular stresses to inhibit cell cycle progression and act as protective mechanisms to ensure …

Lymphocytes derived from mice deficient in STAT1 showed reduced apoptosis and
enhanced proliferation in vitro. To understand the involvement of STAT1 in the observed …

Schwann cell proliferation is regulated by multiple growth factors and axonal signals.
However, the molecules that control growth arrest of Schwann cells are not well defined …

We investigated the influence of lovastatin, simvastatin and pravastatin on proliferation and
viability of vascular smooth muscle cells (SMC) in vitro and studied the effects of lovastatin …

Endothelial cells (ECs) are quiescent in normal blood vessels but undergo rapid bursts of
proliferation after vascular injury and during angiogenesis. Here we show that the activity of …

The retinoblastoma family proteins pRB, p107, and p130 are phosphorylated and released
from E2Fs in the late G 1 phase of the cell cycle. This phosphorylation is thought to …

Apoptotic cell death caused by doxorubicin, a chemotherapeutic agent, is suppressed by
expression of p21 (waf1/cip1/sdi1), a cyclin‐dependent kinase (cdk) inhibitor. To examine …

As cell cycle regulators whose activity is frequently altered in human cancers, cyclin-
dependent kinases (cdks) are novel targets for therapeutic intervention. cdk inhibition is an …

Results of treatment in childhood acute lymphoblastic leukaemia (ALL) remain
unsatisfactory because relapses occur even after high‐dose chemotherapy …

TGFβ1 is a potent growth inhibitor of both primitive and more differentiated human myeloid
leukemic cells. The extent of the growth inhibitory response to TGFP varies with cell type …