The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …

▪ Abstract Adipogenesis, or the development of fat cells from preadipocytes, has been one of
the most intensely studied models of cellular differentiation. In part this has been because of …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors belonging to the nuclear receptor family. PPARs function as regulators of lipid and …

A lesson learned from modern developmental biology is the striking degree of conservation
of strategies and molecules used to program developmental events in species as diverse as …

Fasting is associated with significant changes in nutrient metabolism, many of which are
governed by transcription factors that regulate the expression of rate-limiting enzymes. One …

To determine the physiological roles of peroxisome proliferator-activated receptor β
(PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of …

On diabetes: insulin resistance insulin-resistant study groups in man. In terms of human
studies, TZDs have been most extensively evaluated in patients with type 2 diabetes. Initial …

Peroxisome proliferator-activated receptors, PPARs,(NR1C) are nuclear hormone receptors
implicated in energy homeostasis. Upon activation, these ligand-inducible transcription …

The peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors
belonging to the nuclear receptor superfamily. Until recently, the genes regulated by PPARs …