Several independent pathophysiological mechanisms in both the peripheral and central
nervous system are responsible for sensory symptoms as well as spontaneous and evoked …

Tachykinin NK 1 receptor antagonists have failed to exhibit efficacy in clinical trials of a
variety of clinical pain states. By contrast, in preclinical studies in animals NK 1 receptor …

In 1900, Sherringtongl, 92 was among the first modern neural scientists to define pain as the
psychical adjunct to an imperative protective reflex. This is a concise definition, and it …

In 1949, Rocha e Silva and collaborators reported the existence of a new relaxing
substance, liberated in plasma by the action of the snake venom of Bothrops jararaca or by …

Background: Calcitonin gene-related peptide (CGRP) is involved in the pathophysiology of
migraine and cluster headache. Whether CGRP has any role in chronic tension-type …

Local events in the milieu of injured peripheral nerve trunks may have an important
influence on the likelihood of regenerative success or the development of neuropathic pain …

We determined the co-expression of immunoreactivity (IR) for ATP-receptor subunits (P2X1,
P2X2, and P2X3), neuropeptides, neurofilament (NF), and binding of the isolectin B4 from …

Woolf et al have recently called for the development of a mechanism-based pain taxonomy
to guide the individualization of treatment based on each patient's pain mechanisms …

The precise nature of neurokin receptor involvement in human immune cell chemotaxis is
unclear. This study therefore sought to directly compare the chemotactic effects of …

Kronik a rı sık rastlanan klinik bir bulgudur ve muhtemelen doktora ba vurmaya en sık neden
olan belirtidir. Kronik a rı nedeniyle yapılan sa lık hizmeti masrafları son derece yüksektir …