Calcitonin (CT), a 32 amino acid peptide hormone produced primarily by the thyroid, and its
receptor (CTR) are well known for their ability to regulate osteoclast mediated bone …

Islet amyloid polypeptide (IAPP), or amylin, was originally discovered as the constituent
peptide in amyloid occurring in human insulinomas and in pancreatic islets in human …

Receptor activity modifying proteins (RAMPs) constitute a group of three proteins,
designated as RAMP1, 2, and 3, which are able to effect functional changes in some …

Islet amyloid polypeptide (IAPP) and insulin are expressed in the β-cells of the islets of
Langerhans. They are co-secreted in response to changes in glucose concentration, and …

Islet amyloid polypeptide (IAPP or amylin) potently reduces food intake in rats at or near
physiological concentrations. Although the mechanisms of action of IAPP are not …

Islet amyloid polypeptide (IAPP or amylin) is a normal secretory product of the pancreatic
beta-cell that is cosecreted with insulin and is the major constituent of islet amyloid deposits …

Amylin is a pancreatic peptide that has been shown to be able to induce a state of peripheral
insulin resistance. Hyperamylinaemia, which occurs in type 2 diabetes, may be central to a …

Viewpoint caused insulin resistance and obesity and that “hyperamylinaemia” was a cause
of type 2 diabetes. 16 In addition, it was considered that amylin replacement might prove …

In the early 1980s, Amara et al.(1982) discovered that the alternative splicing of the
calcitonin (CT) gene leads to the formation of a new peptide, called the calcitonin gene …

Nitric oxide (NO) released from endothelium plays an important role in CGRP induced
endothelium-dependent vasorelaxation. A dual signal transduction pathway including cyclic …