Interleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and
expressed at low levels, except during infection, trauma, or other stress. Among several …

Oxygen-derived free radicals are important in both natural and acquired immunity.
Neutrophil and macrophage phagocytosis stimulates various cellular processes including …

Ageing is associated with increased inflammatory activity in the blood. The purpose of this
study was to investigate if age-related increased plasma levels of TNF-α were associated …

In the past 100 y, there has been a dramatic increase in the number and proportion of
people living into old age in Western countries. The proportion of the population that is …

Pedersen BK, Bruunsgaard H, Ostrowski K, Krabbe K, Hansen H, Krzywkowski K, Toft A,
Søndergaard SR, Petersen EW, Ibfelt T, Schjerling P. Cytokines in Aging and Exercise. Int J …

Systemic inflammation, represented in large part by the production of pro-inflammatory
cytokines, is the response of humans to the assault of the non-self on the organism. Three …

Although an array of physiologic alterations occur in older persons, the fundamental
mechanisms that account for these changes are not well understood. Changes such as …

Human immune responses are the result of interactions among diverse components of the
body's immune system. The primary reason for the existence of such a complex system is to …

Background Older individuals are at increased risk for myelosuppression, the most common
complication of cytotoxic chemotherapy. Causes include reduction in hemopoietic stem cell …

Data from animal and in vitro studies suggest that the growth-promoting effects of the
adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by …