Investigation of effective anesthesia induction doses using a wide range of infusion rates with undiluted and diluted propofol
T Kazama, K Ikeda, K Morita, M Kikura… - The Journal of the …, 2000 - pubs.asahq.org
Background The influence of infusion rate on the induction dose-response relation has not
been investigated over a wide range of infusion rates. In this study, the authors defined the …
been investigated over a wide range of infusion rates. In this study, the authors defined the …
Isoflurane alters the recirculatory pharmacokinetics of physiologic markers
MJ Avram, TC Krejcie, CU Niemann… - The Journal of the …, 2000 - pubs.asahq.org
Background Earlier studies have demonstrated that physiologic marker blood
concentrations in the first minutes after administration, when intravenous anesthetics exert …
concentrations in the first minutes after administration, when intravenous anesthetics exert …
The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep
Background Thiopental and propofol are highly lipid-soluble, and their entry into the brain
often is assumed to be limited by cerebral blood flow rather than by a diffusion barrier …
often is assumed to be limited by cerebral blood flow rather than by a diffusion barrier …
Relationships between steady state blood concentrations and cardiac output during intravenous infusions
RN Upton - Biopharmaceutics & drug disposition, 2000 - Wiley Online Library
The blood concentration of a drug at steady state can be calculated from the ratio of infusion
rate over the total body drug clearance. When the blood is assumed to be a homogenous …
rate over the total body drug clearance. When the blood is assumed to be a homogenous …