Compositions for targeting the vasculature of solid tumors
PE Thorpe, FJ Burrows - US Patent 6,051,230, 2000 - Google Patents
2008-10-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production
MEM Weijtens, EH Hart, RLH Bolhuis - Gene therapy, 2000 - nature.com
Genetically engineered expression of tumor-specific single chain antibody chimeric
receptors (ch-Rec) on human T lymphocytes endow these cells with the parental …
receptors (ch-Rec) on human T lymphocytes endow these cells with the parental …
Antibody‐conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes
B Robert, P Guillaume, I Luescher… - European journal of …, 2000 - Wiley Online Library
To demonstrate that antibody‐guided targeting of antigenic MHC class I‐peptide tetramer on
tumor cells can render them susceptible to lysis by relevant cytotoxic T lymphocytes (CTL) …
tumor cells can render them susceptible to lysis by relevant cytotoxic T lymphocytes (CTL) …
Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes
A number of cell surface molecules with specificity to tumour cells have been identified and
monoclonal antibodies (mAb) to some of these antigens have been used for targeting …
monoclonal antibodies (mAb) to some of these antigens have been used for targeting …
Redirected cellular cytotoxicity by infection of effector cells with a recombinant vaccinia virus encoding a tumor-specific monoclonal antibody
S Paul, N Bizouarne, K Dott, L Ruet, P Dufour… - Cancer Gene …, 2000 - nature.com
Cytotoxicity is an important function of the immune system that results in the destruction of
cellular targets by humoral and/or cellular mechanisms. We wanted to assess the possibility …
cellular targets by humoral and/or cellular mechanisms. We wanted to assess the possibility …
Synthesis of bifunctional antibodies for immunoassays
BS DeSilva, GS Wilson - Methods, 2000 - Elsevier
The synthesis of bifunctional antibodies using the principle of solid-phase synthesis is
described. Two Fab′ fragments were chemically linked together via a bismaleimide …
described. Two Fab′ fragments were chemically linked together via a bismaleimide …
Treatment of patients with malignant lymphomas with monoclonal antibodies
H Tesch, A Engert, O Manzke, V Diehl… - Bone Marrow …, 2000 - nature.com
Malignant lymphomas represent a heterogenous group of B and T cell-derived
malignancies. Most lymphomas are sensitive to chemo-and radiotherapy, however many …
malignancies. Most lymphomas are sensitive to chemo-and radiotherapy, however many …