Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

A Diefenbach, AM Jamieson, SD Liu, N Shastri… - Nature …, 2000 - nature.com
Natural killer (NK) cells attack tumor and infected cells, but the receptors and ligands that
stimulate them are poorly understood. Here we report the expression cloning of two murine …

Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

JL Matsuda, OV Naidenko, L Gapin… - The Journal of …, 2000 - rupress.org
A major group of natural killer (NK) T cells express an invariant Vα14+ T cell receptor (TCR)
specific for the lipoglycan α-galactosylceramide (α-GalCer), which is presented by CD1d …

Early signaling via inhibitory and activating NK receptors

M Bléry, L Olcese, E Vivier - Human immunology, 2000 - Elsevier
This review focuses on recent findings on the structural features of inhibitory NK cell
receptors containing immunoreceptor tyrosine-based inhibition motif (ITIM) and of NK cell …

Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand

JC Boyington, SA Motyka, P Schuck, AG Brooks… - Nature, 2000 - nature.com
Target cell lysis is regulated by natural killer (NK) cell receptors that recognize class I MHC
molecules. Here we report the crystal structure of the human immunoglobulin-like NK cell …

HLA class I recognition by killer cell Ig-like receptors

EO Long, S Rajagopalan - Seminars in immunology, 2000 - Elsevier
Copyright 2000 Academic PressNatural killer (NK) cell activation is regulated by a
combination of positive and negative signals coming from repertoires of activating and …

Analysis of Qa-1bPeptide Binding Specificity and the Capacity of Cd94/Nkg2a to Discriminate between Qa-1–Peptide Complexes

JR Kraft, RE Vance, J Pohl, AM Martin… - The Journal of …, 2000 - rupress.org
The major histocompatibility complex class Ib protein, Qa-1b, serves as a ligand for murine
CD94/NKG2A natural killer (NK) cell inhibitory receptors. The Qa-1b peptide-binding site is …

Memory CD8 T lymphocytes express inhibitory MHC‐specific Ly49 receptors

MC Coles, CW McMahon, H Takizawa… - European Journal of …, 2000 - Wiley Online Library
Natural killer (NK) cells survey potential targets using an array of receptors specific for major
histocompatibility complex class I molecules. In mice, members of the Ly49 receptor gene …

[HTML][HTML] Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC

C Roth, JR Carlyle, H Takizawa, DH Raulet - Immunity, 2000 - cell.com
We report an in vitro stroma-dependent system for the clonal growth and differentiation of
natural killer (NK) cells from lymphoid-restricted bone marrow progenitors or bone marrow …

NK cell expression of the killer cell lectin‐like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules

L Corral, T Hanke, RE Vance, D Cado… - European journal of …, 2000 - Wiley Online Library
Using a new mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termedkiller
cell lectin‐like receptor G1'(KLRG1; formerly mouse MAFA or 2F1‐Ag). KLRG1 is expressed …

Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers

J Michaëlsson, A Achour, M Salcedo… - European journal of …, 2000 - Wiley Online Library
Murine natural killer (NK) cells are inhibited from killing their targets by the interaction
between inhibitory, C‐type lectin like Ly49 receptors and major histocompatibility complex …