Spheroids are tridimensional aggregates of tumor cells coming from one or several cell
clones. This model, which mimics the micro-tumors structure and some of their properties …

The outer cells of Chinese hamster V79 spheroids are about 10 times more resistant than
monolayers to DNA damage and cell killing by the topoisomerase (topo) II inhibitor …

Background. Cancer cells maintained in monolayer tissue culture are frequently used to
study tumor biology and nutrient uptake, but there is a concern that this system may not fully …

Earlier mathematical models of the authors which describe avascular tumour growth are
extended to incorporate the process of cell shedding, a feature known to affect the growth of …

The in vitro self-assembly of multicellular spheroids generates highly organized structures in
which the three-dimensional structure and differentiated function frequently mimic that of in …