Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

E Buchdunger, CL Cioffi, N Law, D Stover… - … of Pharmacology and …, 2000 - ASPET
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is
currently in clinical trials for the treatment of chronic myelogenous leukemia. STI571 …

Clinical use of tyrosine kinase inhibitors: therapy for chronic myelogenous leukemia and other cancers

NJ Donato, M Talpaz - Clinical Cancer Research, 2000 - AACR
Since the initial discovery of tyrosine-specific protein kinases encoded by transforming
viruses and their normal cellular homologues, there has been a great deal of interest in …

Dragons' round the fleece again: STI571 versus α1 Acid Glycoprotein

EA Sausville - Journal of the National Cancer Institute, 2000 - academic.oup.com
Ovid recounts the story of Jason and his Argonauts (1), who, after dealing with jealous
harpies, wandering rocks, spectral armies, and fire-snorting bulls, approach the Golden …