Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity

JA Ledbetter, LK Gilliland - US Patent 6,010,902, 2000 - Google Patents
The present invention relates to novel antibody heteroconjugates and bispecific antibodies
and methods and compositions and their use in the enhancement or inhibition of activation …

Bispecific antibody effective to treat B-cell lymphoma and cell line

G Weiner, R Gingrich, BK Link, JY Tso - US Patent 6,129,914, 2000 - Google Patents
The invention provides bispeci? c antibodies With selective cytotoxicity against malignant B-
cells. The bispeci? c anti bodies bind to an effector cell antigen and to a 28/32 kDa …

Bispecific antibodies, methods of production and use thereof

D Ring, TX Shi - US Patent 6,106,833, 2000 - Google Patents
This invention relates generally to the field of immunology, in particular that of antibodies
and antibody productions. More Specifically, this invention relates to bispecific antibodies …

Apo-2 ligand

AJ Ashkenazi - US Patent 6,030,945, 2000 - Google Patents
57 ABSTRACT A novel cytokine, designated Apo-2 ligand, which induces mammalian cell
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …

Bispecific heteroantibodies with dual effector functions

MW Fanger, PM Guyre, ED Ball - US Patent 6,071,517, 2000 - Google Patents
Bispecific molecules which react both with the high-affinity Fcγ receptor of human effector
cells and with a target cell surface antigen are disclosed. Binding of the molecules to the Fc …

Uses of Wnt polypeptides

W Matthews, TW Austin - US Patent 6,159,462, 2000 - Google Patents
LNAZSHAWQACDHT-XIYTZBAFSA-N (2R, 3R, 4S, 5R, 6S)-4, 5-dimethoxy-2-
(methoxymethyl)-3-[(2S, 3R, 4S, 5R, 6R)-3, 4, 5-trimethoxy-6-(methoxymethyl) oxan-2-yl] oxy …

Apo-2 ligand

AJ Ashkenazi, A Chuntharapai, KJ Kim - US Patent 6,046,048, 2000 - Google Patents
57 ABSTRACT A novel cytokine, designated Apo-2 ligand, which induces mammalian cell
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …

Methods of stimulating or enhancing the immune system with anti-CD3 antibodies

JA Bluestone - US Patent 6,113,901, 2000 - Google Patents
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or
otherwise modify immune responses, and methods for their preparation and use in vivo …

Methods of promoting immunopotentiation and preparing antibodies with anti-CD3 antibodies

JA Bluestone - US Patent 6,143,297, 2000 - Google Patents
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or
otherwise modify immune responses, and method for their preparation and use in vivo …

Cellular and serum protein anchors and conjugates

P Pouletty, C Pouletty - US Patent 6,103,233, 2000 - Google Patents
BACKGROUND Delivery of therapeutic agents to a mammalian host can frequently be as
important as the activity of the drug in providing effective treatment. For the most part, drugs …