Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
JA Ledbetter, LK Gilliland - US Patent 6,010,902, 2000 - Google Patents
The present invention relates to novel antibody heteroconjugates and bispecific antibodies
and methods and compositions and their use in the enhancement or inhibition of activation …
and methods and compositions and their use in the enhancement or inhibition of activation …
Bispecific antibody effective to treat B-cell lymphoma and cell line
The invention provides bispeci? c antibodies With selective cytotoxicity against malignant B-
cells. The bispeci? c anti bodies bind to an effector cell antigen and to a 28/32 kDa …
cells. The bispeci? c anti bodies bind to an effector cell antigen and to a 28/32 kDa …
Bispecific antibodies, methods of production and use thereof
D Ring, TX Shi - US Patent 6,106,833, 2000 - Google Patents
This invention relates generally to the field of immunology, in particular that of antibodies
and antibody productions. More Specifically, this invention relates to bispecific antibodies …
and antibody productions. More Specifically, this invention relates to bispecific antibodies …
Apo-2 ligand
AJ Ashkenazi - US Patent 6,030,945, 2000 - Google Patents
57 ABSTRACT A novel cytokine, designated Apo-2 ligand, which induces mammalian cell
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …
Bispecific heteroantibodies with dual effector functions
MW Fanger, PM Guyre, ED Ball - US Patent 6,071,517, 2000 - Google Patents
Bispecific molecules which react both with the high-affinity Fcγ receptor of human effector
cells and with a target cell surface antigen are disclosed. Binding of the molecules to the Fc …
cells and with a target cell surface antigen are disclosed. Binding of the molecules to the Fc …
Uses of Wnt polypeptides
W Matthews, TW Austin - US Patent 6,159,462, 2000 - Google Patents
LNAZSHAWQACDHT-XIYTZBAFSA-N (2R, 3R, 4S, 5R, 6S)-4, 5-dimethoxy-2-
(methoxymethyl)-3-[(2S, 3R, 4S, 5R, 6R)-3, 4, 5-trimethoxy-6-(methoxymethyl) oxan-2-yl] oxy …
(methoxymethyl)-3-[(2S, 3R, 4S, 5R, 6R)-3, 4, 5-trimethoxy-6-(methoxymethyl) oxan-2-yl] oxy …
Apo-2 ligand
AJ Ashkenazi, A Chuntharapai, KJ Kim - US Patent 6,046,048, 2000 - Google Patents
57 ABSTRACT A novel cytokine, designated Apo-2 ligand, which induces mammalian cell
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …
apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine …
Methods of stimulating or enhancing the immune system with anti-CD3 antibodies
JA Bluestone - US Patent 6,113,901, 2000 - Google Patents
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or
otherwise modify immune responses, and methods for their preparation and use in vivo …
otherwise modify immune responses, and methods for their preparation and use in vivo …
Methods of promoting immunopotentiation and preparing antibodies with anti-CD3 antibodies
JA Bluestone - US Patent 6,143,297, 2000 - Google Patents
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or
otherwise modify immune responses, and method for their preparation and use in vivo …
otherwise modify immune responses, and method for their preparation and use in vivo …
Cellular and serum protein anchors and conjugates
P Pouletty, C Pouletty - US Patent 6,103,233, 2000 - Google Patents
BACKGROUND Delivery of therapeutic agents to a mammalian host can frequently be as
important as the activity of the drug in providing effective treatment. For the most part, drugs …
important as the activity of the drug in providing effective treatment. For the most part, drugs …