Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

LJMJ Vanderschuren, PW Kalivas - Psychopharmacology, 2000 - Springer
Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

[PDF][PDF] Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction

JL Cornish, PW Kalivas - The Journal of neuroscience, 2000 - Soc Neuroscience
Elevated dopamine transmission in the nucleus accumbens is thought to be a primary
mediator of addiction to cocaine. However, repeated exposure to cocaine is associated with …

Dissociation of primary and secondary reward-relevant limbic nuclei in an animal model of relapse

JW Grimm, RE See - Neuropsychopharmacology, 2000 - Elsevier
The neural substrates underlying relapse to drug-seeking behavior after chronic drug abuse
may differ from those underlying immediate drug-taking behavior. In a model of relapse to …

Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats

GM Sizemore, C Co, JE Smith - Psychopharmacology, 2000 - Springer
Rationale: Dopamine innervation of the nucleus accumbens is thought to have a major role
in the biological processes underlying cocaine self-administration. Recent data suggest that …

[图书][B] An investigation of the environmental and neurobiological substrates of conditioned relapse to cocaine-seeking behavior

PJ Kruzich - 2000 - search.proquest.com
Two studies were conducted to investigate the environmental and neurobiological factors
involved in conditioned reinstatement of cocaine-seeking behavior in an extinction …